pentobarbital will reduce the extent or result of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the level or result of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Average CYP3A4 inducers may perhaps lessen progestin concentration; contemplate usage of further barrier approaches
Nursing mothers: Caution really should be exercised whenever a barbiturate is administered to some nursing lady since little quantities of barbiturates are excreted while in the milk.
pentobarbital will lessen the extent or result of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will lessen the extent or effect of alfuzosin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
pentobarbital will lessen the level or impact of cyclosporine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lower the level or influence of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital increases toxicity of methoxyflurane by escalating metabolism. Contraindicated. Greater metabolism of methoxyflurane to nephrotoxic compounds.
Barbiturates are weak acids which might be absorbed and speedily distributed to all tissues and fluids with high concentrations in the Mind, liver, and kidneys. Lipid solubility on the barbiturates would be the dominant Think about their distribution throughout the overall body.
pentobarbital will reduce the level or result of ixabepilone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
benzhydrocodone/acetaminophen and pentobarbital both enhance sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom different procedure alternatives are insufficient
Although the medical literature abounds with statements the limited-performing barbiturates are top-quality for producing slumber though the intermediate-performing compounds are simpler in retaining snooze, controlled scientific studies have failed to demonstrate these differential consequences. Hence, as snooze drugs, the barbiturates are of constrained value beyond shorter-expression use.
pentobarbital will minimize the extent or impact of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Robust or moderate CYP3A4 inducers may perhaps enhance more info charge of diazepam elimination; consequently, efficacy of diazepam may be lessened.
pentobarbital will lessen the level or influence of nisoldipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.